Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (2025)

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Abstract Access this article Subscribe and save Buy Now Similar content being viewed by others Synthesis and immobilization of polystyreneb-polyvinyltriethoxysilane micelles Preparation of surface-modified monodisperse polystyrene microspheres with cationic functional comonomer Monodisperse polystyrene microspheres containing quaternary ammonium salt groups by two-stage dispersion polymerization: effect of reaction parameters on particle size and size distribution Explore related subjects References Acknowledgment Author information Authors and Affiliations Corresponding author Electronic supplementary material Supporting information Rights and permissions About this article Cite this article Keywords References

Abstract

Block copolymers poly(styrene-alt-maleic anhydride)-b-polystyrene (P(St-alt-MAn)-b-PSt) were synthesized via radical addition fragmentation chain transfer copolymerization. The maleic anhydride-containing segments of the block copolymer were hydrolyzed to form amphiphilic poly(styrene-alt-maleic acid)-b-polystyrene (P(St-alt-MA)-b-PSt). In aqueous solution, P(St-alt-MA)73-b-PSt81 and P(St-alt-MA)58-b-PSt130 formed stable dispersed spherical aggregates of approximately 25 and 40nm, respectively. Particle size was stable under alkaline conditions and was little affected by the polymer concentration in the range of 0.025–1.0mg mL−1. The critical aggregation concentrations of the block copolymer self-aggregates were 1 × 10−3 and 3 × 10−3mg mL−1 for hydrophobic PSt block lengths of 130 and 81 monomer units, respectively. The nanoparticles had a negative surface charge at pH > 2. Scanning electron microscopy images revealed that particle–particle coalescence did not occur upon drying of the film and the nanoparticles remained discrete. Controlled aspirin release from the nanoparticles was dependent on the structure of the block polymers and release medium.

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Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (1)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (2)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (3)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (4)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (5)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (6)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (7)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (8)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (9)
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (10)

Similar content being viewed by others

Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (11)

Synthesis and immobilization of polystyreneb-polyvinyltriethoxysilane micelles

Article 31 January 2018

Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (12)

Preparation of surface-modified monodisperse polystyrene microspheres with cationic functional comonomer

Article 14 December 2018

Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (13)

Monodisperse polystyrene microspheres containing quaternary ammonium salt groups by two-stage dispersion polymerization: effect of reaction parameters on particle size and size distribution

Article 18 November 2020

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Acknowledgment

This research was funded by the New Zealand Foundation for Research, Science and Technology (Contract CO8X0409, Multiscale Modelling Programme). We thank Liz Girvan and the Otago Centre for Electron Microscopy (OCEM) for the assistance with electron microscopy.

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Authors and Affiliations

  1. Department of Food Science, University of Otago, P.O. Box 56, Dunedin, New Zealand

    Jingtian Han,Patrick Silcock&Phil Bremer

  2. Department of Chemistry, University of Otago, P.O. Box 56, Dunedin, New Zealand

    A. James McQuillan

Authors

  1. Jingtian Han

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  2. Patrick Silcock

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  3. A. James McQuillan

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  4. Phil Bremer

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Corresponding author

Correspondence to Patrick Silcock.

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Han, J., Silcock, P., McQuillan, A.J. et al. Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles. Colloid Polym Sci 286, 1605–1612 (2008). https://doi.org/10.1007/s00396-008-1934-7

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  • DOI: https://doi.org/10.1007/s00396-008-1934-7

Keywords

  • Polymer nanoparticles
  • Self-aggregation
  • Diblock copolymer
  • RAFT copolymerization
  • Controlled release
Preparation and characterization of poly(styrene-alt-maleic acid)-b-polystyrene block copolymer self-assembled nanoparticles (2025)

References

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